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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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Here are the key drug-food Interactions:

  1. Grapefruit and Grape Juice: Grapefruit can increase the levels of tadalafil by inhibiting the enzyme alpha-adrenergic receptor 14 (AR14) that tighten blood vessels.
  2. : Though not a direct interaction, combining Cialis with grapefruit or grapefruit juice might worsen side effects in sensitive individuals.
  3. McIntyre’s Pills: While taking Pills, taking a dose of Cialis may alter the blood pressure-lowering effects of the medication, may increase the risk of side effects like dizziness or drowsiness.
  4. Other Pills: Someasthios (e.g., sildenafil) is used to treat pulmonary hypertension, high blood pressure, and certain types of cancer.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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As with all prescription medications, inform your doctor of any medical conditions you used to get pregnant, or started sex. Even if you have, it’s important to follow their instructions for when to discontinue Cialis.

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If you are pregnant, planning to become pregnant, or are breastfeeding, become smoking-free ( Fn = lung) or use illegal drugs, do not breastfeed. They may interact with Cialis. If you have any underlying health conditions, talk to your health care provider.

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If you are a woman, use this medication only as directed; avoid alcohol, recreational drugs, and herbal supplements, as this can interact with Cialis. Do not take Cialis with any nitrate medication, including nitroglycerin, or nitrostatins, as it can cause a drop in blood pressure.

Do not take Cialis with any other drug--alcohol, prescription or nonprescription--so do not take it if you have had a heart attack, irregular heart, or stroke within the last 90 days.

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Cialis can interact with other medications, including nonprescription Cialis, nitrates, and alpha-blockers. Inform your health care provider of all medications you are taking.

In addition, let your doctor know if you are taking any antifungal, HIV protease inhibitors, or high blood pressure medication before starting Cialis. These can interact with voriconazole, sildenafil, tadalafil, or any other Cialis waive effect.

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These can interact with voriconazole, sildenafil, tadalafil, or any other Cialis pharmacologic class restrictions.

They may need to adjust your dosage according to your response. They may need to use a longer time to achieve the same effect.

If you experience any side effects while taking Cialis, contact your doctor.

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Cialis vs Tadalafil: How Cialis Helps Us Get Rid of Erectile Dysfunction

Erectile dysfunction (ED), a common condition, is often a result of physical, psychological and emotional factors. It's not just physical, it's emotional. The good news is that Cialis is the medication that helps to improve erectile function by increasing blood flow to the penis, which is needed to get and keep an erection. In fact, when men with ED struggle with getting or keeping an erection, it can be quite a challenge to find the right treatment. Fortunately, there are various medications available for erectile dysfunction, such as Cialis and Tadalafil. The primary goal of these medications is to help men get and maintain an erection. However, the choice of medication may come down to personal preference and how best to manage the health condition. In this article, we'll explore everything you need to know about erectile dysfunction and its treatment, including how Cialis works, how to take it, and how to use it.

1. What Is Erectile Dysfunction?

Erectile dysfunction, or ED, is the inability to get and keep an erection hard enough for sexual activity. It can stem from physical factors such as: 1. Physical problems such as heart disease, high blood pressure, diabetes, high cholesterol, high blood pressure, or high blood pressure.

2. Psychological issues such as stress, anxiety, depression, and relationship issues.

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11. Psychological issues such as anxiety, stress, depression, and relationship issues.

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What is Tadalafil (Cialis)?

Tadalafil (Cialis) is a Food and Drug Administration (FDA) approved prescription medicine used to treat (ED). It is also used to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia - BPH).

Tadalafil is the active ingredient in the brand Adcirca. Adcirca is prescribed to treat high blood pressure in your lungs, known as pulmonary arterial hypertension (PAH), and improve the ability to exercise. It does this by causing the blood vessels in the lungs to relax. This increases the supply of blood to the lungs and reduces the workload of the heart. Both men and women can take Tadalafil for PAH however, women cannot take Tadalafil to treat ED.

Tadalafil is also the active ingredient of the branded treatment Cialis. While both medications have similar effectiveness in treating ED, there may be minor differences in the other added ingredients and price.

How does Tadalafil work?

Tadalafil works to treat erectile dysfunction by increasing the blood flow to the penis during sexual stimulation. It belongs to a class of medications called phosphodiesterase type-5 inhibitors (PDE-5).

An erection occurs when sexual arousal stimulates the brain. Tadalafil inhibits PDE-5, leading to increased levels of the substance cGMP within the chambers of the penis, known as the corpus cavernosum. This causes the smooth muscle in the penis to relax and an inflow of blood to the area. This increased blood flow causes an erection.

Tadalafil can only cause an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. After ejaculation, the effects will wear off but it will work if you are aroused again.

How should I take Tadalafil?

Tadalafil is intended for treating ED only by real people. It should not be used by individuals with an history of any other medical condition, including following a stroke, heart, or blood pressure heart disease or any heart attack.

When taking Tadalafil, you should:

  • Avoid excessive sunlight as well as artificial UV rays
  • Avoid consuming high-fat meals or oily foods with the active ingredient Tadalafil
  • Tadalafil can also interact with other medications and substances, causing potentially serious issues.
  • Tadalafil should not be taken with Tadalafil containing medications used for nitrates, such as nitroglycerin, which is a strong Antihyperglycosides drug. A small amount of gums the medicine against nitrates. This can lead to potentially high blood pressure and fainting. A missed dose can cause heart problems.
  • Tadalafil can only be taken on an “ED date” when the person who currently has ED has it, such as today, Mar-Aug-1970.

Tadalafil will not treatallerections that can occur with sexual stimulation.

What is the difference between Tadalafil 1 1mg and Adcirca?

Tadalafil 1 1mg is a combination of two active ingredients: Tadalafil 1 mg and Adcirca 1 mg. The active ingredient, 1 mg of Tadalafil, which works by inhibiting an enzyme in the process of erectile dysfunction, is Tadalafil 5 mg. The recommended starting dose for both Tadalafil 1 1mg and Adcirca is 5 mg, taken as needed approximately 1 hour before sexual activity.

How should Tadalafil be taken?

Tadalafil is to be taken 25mg on an “ED” date when the person who has BPH has it. Tadalafil should not be taken more than once a day. As with any prescription medicine, it may cause side effects, such as heart problems ora decrease in your blood pressure. It may also cause taking Tadalafil to make the blood vessels in the lungs less dilated. This lowers blood pressure and in turn, the heart rate. This should improve. The onset of these effects will vary from person to person, but they typically improve with time.

.Tadalafil 1 1mg may be taken with or without food.